20 February 2020 from 12:45 to 13:45

Promotion: Female reproductive health: Species and ligand-specific endometrial responses to hormones and aryl hydrocarbon receptor activation

Over 10% of women in their reproductive age is affected by diseases of the female reproductive system. These diseases have been linked tot he exposure of environmental contaminants. However, the interplay between the brain, ovaries and uteris makes this system challenging to study. This is partly why experimental testing strategies addressing the effects of chemicals on female reproductive health are largely lacking. In this thesis, a human relevant endometrial model using primary human uterine cells was established to assess the differences between the endometrium of human and rat.
The research described in this thesis shows that there are significant differences between te human and rat endometrium. This can hamper the translation of animal studies to the human situation. Cellular responses to hormones differs between the endometrium of humans and rats, but also the responses to aryl hydrocarbon receptor activators differs between humans and rats. Thus, the rat may not be a suitable model to assess the effects of chemicals on female reproductive health. The use of a human relevant endometrial model with primary cells can possibly lead to a better understanding of potential endometrial health effects of chemicals.

Start date and time
20 February 2020 12:45
End date and time
20 February 2020 13:45
PhD candidate
A.D. van den Brand
Dissertation
Female reproductive health: Species and ligand-specific endometrial responses to hormones and aryl hydrocarbon receptor activation
PhD supervisor(s)
prof. dr. M. van den Berg prof. dr. M.B.M. van Duursen