PhD Defense: Patient-Tailored Cardiac Resynchronization Therapy: Imaging and Exercise Strategies

PhD Defense of Philippe Constant Wouters

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Cardiac resynchronization therapy (CRT) is a pacemaker therapy used in patients with severe heart failure and an electrical conduction disturbance of the left ventricle. Because one in three patients experience insufficient improvement after this treatment. this goal of this thesis was to improve outcomes after CRT.

In the first part, a new method to objectively and automatically analyze the standard 12-lead electrocardiogram was developed. As a result, the chance of response after CRT can easily be determined. In addition, the added value of simultaneous assessment of mechanical left ventricular dysfunction using echocardiography was demonstrated. Both approaches allow for a relatively easy to use method to improve patient selection. In the second part, the importance of patient-tailored placement of the left ventricular lead is discussed, and the challenges that arise with this approach. The feasibility of image-guided placement of the left ventricular lead was shown in three Dutch centers. Finally, the diagnostic, prognostic, and therapeutic role of exercise in CRT was explored. We found that both exercise training and CRT are important to improve functional recovery in patient with heart failure.

Start date and time
End date and time
Location
Academiegebouw, Domplein 29 & online (livestream link)
PhD candidate
P.C. Wouters
Dissertation
Patient-Tailored Cardiac Resynchronization Therapy: Imaging and Exercise Strategies
PhD supervisor(s)
prof. dr. P.A.F.M. Doevendans
prof. dr. F.W. Prinzen
Co-supervisor(s)
dr. M. Meine
dr. M.J. Cramer
More information
Full text via Utrecht University Repository