16 January 2020 from 10:30 to 11:30

PhD Defence: Steps forward in exercise-oncology research: TwiCs design and wearables

There is substantial evidence on the beneficial effects of physical activity in patients with breast cancer. Therefore, it is important to stimulate physical activity during and after breast cancer treatment, but how physically active are these patients? Also, advances in the device- and smartphone technology offers opportunities for promoting physical activity. The effectiveness of physical activity interventions using wearables and smartphone applications to promote physical were evaluated.

In the field of exercise-oncology research, reported beneficial effects of exercise found on fatigue and quality of life were often small, probably partly caused by shortcomings of the RCT design when evaluating interventions. Who receives the exercise programme is determined by chance. This may be disappointing and patients do not want to participate, they withdraw from the control group or they start exercising on their own. The Trials within Cohorts (TwiCs) design was proposed as an alternative to conventional pragmatic RCTs. The UMBRELLA Fit study used the innovative Trials within Cohorts design to examine the effectiveness of a 12-week exercise intervention on the quality of life and fatigue of inactive patients with breast cancer.

This thesis describes the UMBRELLA Fit study that used the innovative TwiCs design, from design to analyses. In addition, the challenges and benefits when conducting a trial within a cohort compared to conventional exercise-oncology RCTs were describes, as well as the results of the UMBRELLA Fit study. Based on our experiences, we developed a practical guide that can be used in designing future pragmatic exercise-oncology trials using the TwiCs design.

Start date and time
16 January 2020 10:30
End date and time
16 January 2020 11:30
PhD candidate
Roxanne Gal
Steps forward in exercise-oncology research: TwiCs design and wearables
PhD supervisor(s)
Prof. P.H.M. PeetersProf. A.M. May
dr. E.M. Monninkhof
Entrance fee