25 June 2019 from 12:45 to 13:45

PhD Defence: Patient specific cerebral arterial blood flow modelling

Many vascular brain diseases are complex and treatment is often based on experience of the treating physician or small research studies. Usage of a mathematical blood flow model might aid in better treatment selection and more personalized healthcare. The current thesis tried to develop such a patient-specific blood flow model feasible for clinical usage. We initially tested a more complex 3D blood flow model which proofed accurate, however due to its complexity clinical applicability was limited. Hence, we opted for a simplified model. As proximal boundary conditions radial artery cuff pressure measurements were used. The anatomy of the larger arteries of the brain was acquired using MRI. To acquire proper distal boundary conditions information on branching patterns of the vasculature of the brain were needed. These were acquired using high-resolution 7T MRI, 9.4T MRI and traditional manual measurements. These branching patterns combined with a simple autoregulatory model were used to generate distal boundary conditions. A set of simple linear equations based on the well-known Hagen-Poiseuille law were used to calculate flow and pressure. Data of a total of 10 healthy subjects were used do optimize parameters of distal boundary conditions. Data of an additional 20 healthy subjects were used to validate the model. The model showed to be accurate in a range that might proof feasible for clinical usage. This confirms that even simplified models show great potential in complex vascular brain diseases. However, for some specific usage cases more complex models might be needed.

Start date and time
25 June 2019 12:45
End date and time
25 June 2019 13:45
PhD candidate
Jasper Helthuis
Patient specific cerebral arterial blood flow modelling
PhD supervisor(s)
Prof. A. van der Zwan
Prof. T.P.C. van Doormaal
Entrance fee