16 April 2019 from 10:30 to 11:30

PhD Defence: Determining childhood infections and long-term consequences

Infectious diseases are very common in early childhood. On the one hand these infections have a role in the development of a child's immune system, but on the other hand they might also be associated with negative long-term health effects. This thesis first describes different ways of measuring childhood infections in relation to risk factors and long-term health effects. Childhood infections are assessed via antibody measurement and symptom diaries, both paper-based and as smartphone application. The results indicate that the most important risk factors are related to crowding and that the best way of assessing these infections is by asking parents to record the infection-related symptoms of their child in a smartphone diary app. Next, the potential negative long-term health effects of early childhood infectious diseases are described by studying whether the number of general practitioner diagnosed infections, number of antibiotic prescriptions, and number of parent-reported infections are associated with weight and the first signs of development of atherosclerosis in adolescence. The results indicate indeed that frequent childhood infections might be associated with a higher BMI and more atherosclerosis in adolescence.

Start date and time
16 April 2019 10:30
End date and time
16 April 2019 11:30
PhD candidate
Annemarijn Prins-van Ginkel
Dissertation
Determining childhood infections and long-term consequences
PhD supervisor(s)
Prof. H.A. SmitProf. M. van der Sande
Co-supervisor(s)
Prof. P.C.J.L. Bruijning-VerhagenProf. W. van der Hoek
Entrance fee
Free