5 September 2019 from 14:30 to 15:30

PhD Defence: Advancing medical devices for novel image-guided percutaneous cardiac interventions

Heart failure is a complex clinical syndrome, progressive in nature, and about half of the patients who develop heart failure die within 5 years of diagnosis. This is a significant economic and healthcare burden that drives the need for novel and optimized cardiovascular treatment strategies. Current treatment strategies focus on prevention of further left ventricle deterioration and/or improvement of left ventricle function, symptom relief, and prolongation of life. The complexity of cardiac interventions has increased due to technological development and the shift from complex surgical procedures to less invasive transcatheter-based procedures in combination with the rapid introduction of novel medical technology in clinical practice. To optimize the current strategies a major focus has been hybrid imaging technology. Hybrid imaging implicates the integration of multiple imaging modalities to provide visualization of the organs and soft tissues during the intervention.

This thesis describes the development of a new 3D navigation technique based on HI for image-guided cardiac interventions. From bench to bedside we have developed the imaging technology, designed the testing methods, and performed the (pre-)clinical studies to assess its accuracy, clinical safety, and feasibility. The technologies were aimed at improving treatment planning, visualization, and guidance of complex cardiac interventions. The development steps described in this thesis accentuate how a medical technology specialist can be of importance for the clinical translation of medical technology. HI technology is an important technique in the growing need for optimizations of complex cardiovascular interventions of heart failure patients.

Start date and time
5 September 2019 14:30
End date and time
5 September 2019 15:30
PhD candidate
Hans Thijs van den Broek
Advancing medical devices for novel image-guided percutaneous cardiac interventions
PhD supervisor(s)
Prof. S.A.J. ChamuleauProf. P.A.F.M. Doevendans
Prof. F.J. van SlochterenProf. R. van Es
Entrance fee