From 18 November 2019 10:00 to 19 November 2019 13:30

Innovative One-Health approaches in bacterial vaccine development

This conference is set up as the mid-term conference of the Bac-Vactory consortium. Bac-Vactory is a public-private partnership of six Dutch universities/university medical centers and several international pharmaceutical and biotech companies with financial support from NWO-TTW. The consortium started in the beginning of 2017. It exploits knowledge and expertise in both human and animal health as a One-Health approach to develop innovative platform technologies for the production of novel bacterial vaccines for human and animal application.

During the conference, results from the Bac-Vactory consortium will be presented. In addition, several invited speakers, who are renowned scientists in the field, will present their work. There will be opportunities for participants to present their work in posters.

Program Monday 18 November

10.00 – 10.30     Registration, coffee, poster mounting

10.30 – 10.50     Jan Tommassen (Utrecht University): Opening conference

10.50 – 11.50     Antigen discovery

Marien de Jonge (Radboud UMC):  In vivo expression and vaccine antigen discovery

Lucille van Beek (Radboud UMC): Exploring the natural niche of Streptococcus pneumoniae to discover potential vaccine antigens

11.50 – 12.20     Sven Hammerschmidt (University of Greifswald): Immunogenicity and protectivity of novel pneumococcal vaccine candidates

12.20 – 13.45     Lunch and poster viewing

13.45 – 14.45     Whole-cell and outer-membrane vesicle vaccines

Jan Tommassen (Utrecht University): Lipid A engineering for vaccine development

Eline de Jonge (Utrecht University): Improving OMV production in Bordetella pertussis by disrupting lipid homeostasis

Jesús Pérez Ortega (Utrecht University): Lipid A engineering in Bordetella bronchiseptica

14.45 – 15.15     Camille Locht (Institut Pasteur de Lille) : Live attenuated nasal Bordetella vaccine, from concept to clinical development 

15.15 – 15.45     Coffee break

15.45 – 16.45     Autotransporter antigen display

Joen Luirink (VU University): Recombinant Salmonella vaccines as vector for vaccine development

Trang Phan (VU University): Addressing the limited capacity of the Type V secretion system to improve the cell surface display of antigens

Bart van den Berg van Saparoea (Abera Bioscience AB): Decorating bacteria and OMVs using a bacterial glue

16.45 – 17.15     Guido Grandi (University of Trento): Synthetic biology of bacterial outer membrane vesicles (OMVs) for the development of vaccines against infectious diseases and cancer

17.15 – 17.45     Wilbert Bitter (VU University and Amsterdam UMC): Tinkering with the tuberculosis BCG vaccine: can you teach an old dog new tricks?

17.45 – 18.45     Drinks and poster viewing

Program Tuesday 19 November

09.00 – 10.00     Polymer assemblies for antigen display

Jan van Hest (Eindhoven University of Technology): Shape control in polymer assemblies for nanomedicine applications

Pascal Welzen (Eindhoven University of Technology): Multifunctional polymeric nano-vesicles as vaccine delivery platform

10.00 – 10.30     Bruno de Geest (Ghent University): Engineering innate immune activation with amphiphile-conjugated small molecule immunomodulators

10.30 – 11.00     Coffee break

11.00 -  11.30     Xiangdong (Jack) Li (Pulike Biological Engineering): African swine fever in China; what we have done

11.30 – 12.30     Immunomodulation

Henk Haagsman (Utrecht University): Immunomodulation

Maaike Scheenstra (Utrecht University): Innate immune training induced by chicken cathelicidin-2 in mice and chicken

Roel van Harten (Utrecht University): Cathelicidins modulate the immune response of porcine macrophages in a peptide-specific fashion

Melanie Balhuizen (Utrecht University): PMAP-36 reduces the immune response induced by Bordetella bronchiseptica-derived outer membrane vesicles

12.30 -13.00       Volker Gerdts (VIDO-Intervacc and University of Saskatchewan): Reverse Vaccinology for the Development of Vaccines Against Bacterial Diseases

13.00                     Take away lunch

Start date and time
18 November 2019 10:00
End date and time
19 November 2019 13:30