In this course a total of at least 6 animal models with different experimental setups will be covered. The models include myocardial infarction and I/R injury, atherosclerosis, peripheral vascular disease, experimental surgery concerning heart failure, and (stem) cell therapy. Techniques applied cover P/V loops, MRI, perfusion measurements, etc.
Translational research requires adequate models to bridge the gap between in vitro experiments and clinical reality. Animal models basically serve 3 aims: 1) to gain mechanistic insights into (patho) physiological processes; 2) to mimic human disease; and 3) to test experimental therapeutic approaches, either separately or combined.
The aim of this course is to make PhD candidates familiar with cardiovascular animal models used in the different experimental laboratories, but will also shed some light on alternatives for animal experiment. This enables the student to better judge the implications of experimental animal studies, to get a broader view of models with their advantages and disadvantages, and to use these insights to optimize own models.
The course will be given in English and in such a way that both the PhD candidates and the lecturers are able to incorporate this course in their daily work. There will be 10 interactive lectures of a 2 hours total given by different lecturers. Besides theoretical background of cardiovascular experimental models, the PhD students will be given the opportunity to observe animal experiments.. The course will be finished within a time frame of 6 months maximal. This allows for the right planning and visits of animal experiments.
You will be trained by experts in the field. The course coordinators for this course are dr. Saskia C.A. de Jager (Laboratory of Experimental Cardiology, UMCU; email: email@example.com) and prof. Dominique de Kleijn (Vascular Surgery, UMCU, email: firstname.lastname@example.org).
Max. number of participants
16. All PhD students can register, however, if more than 16 persons register, the organization reserves the right to make a selection.
Number of credits
17, 24 September, 1, 15, 22, 29 October, 5, 12, 19, 26 November 2019
9.00 – 10:45 hours
To qualify for the certificate, participants must attend all lectures, animal experiment and complete the assignment satisfactorily. Attendance will be registered.
This course is free of charge for PhD candidates registered at the Graduate School of Life Sciences.