6 May 2019 from 14:30 to 15:30

PhD defence of Wenjing Lu

Blocking the Hemagglutinin of Influenza A Virus by Multivalent Inhibitors

The aim of this thesis is to develop multivalent carbohydrate-based ligands as inhibitors of the adhesion of the Influenza A virus (IAV). The adhesion protein hemagglutinin (HA) plays a central role in the infection process, and has potential as a drug target besides the neuraminidase. HA is a challenging target, since it binds only weakly to its target ligands: sialylated LacNAc derivatives, relying on multivalency for strong viral adhesion. While viral adhesion inhibition by large polymeric molecules has proven viable, limited success was reached for a design based approach to reach the three binding pockets of HA by smaller molecules. By linking sialylated LacNAc units to di- and trivalent scaffolds, inhibitors were obtained with a potent inhibition effect in several assays.

Start date and time
6 May 2019 14:30
End date and time
6 May 2019 15:30
PhD candidate
W. Lu
Dissertation
Blocking the Hemagglutinin of Influenza A Virus by Multivalent Inhibitors
PhD supervisor(s)
Prof. dr. R.J. Pieters