prof. dr. A.M.J.J. (Alexandre) Bonvin
A.M.J.J.Bonvin@uu.nl
Gegenereerd op 2016-02-09 12:41:22


Leeropdracht
Computationele structuurbiologie
Benoemingsdatum 01-09-2009
Profiel

NWO-CW VICI Laureate 2006

Major research interests/expertise:

  • Biomolecular interactions
  • Biomolecular docking
  • Structure and dynamics
  • Biomolecular modelling
  • NMR spectroscopy
  • Computational structural biology

 

 

 

 

Wetenschappelijke expertises
Gegenereerd op 2016-02-09 12:41:23
Curriculum vitae Download PDF

Alexandre Bonvin (1964) studied Chemistry at Lausanne University, Switzerland and obtained his PhD at Utrecht University in the Netherlands (1993). After two post-doc periods at Yale University (USA) and the ETHZ (CH) he joined Utrecht University in 1998 where he was appointed full professor of computational structural biology in 2009. In 2006, he received a prestigious VICI grant from the Dutch Research Council. He was director of chemical education from February 2009 until February 2012 and vice head of the Chemistry Department from 2010 until April 2012. He is participating to several EU projects including the FP7 WeNMR e-Infrastructure project, which he has been coordinating (http://www.wenmr.eu). His work has resulted in over 180 peer-reviewed publications (Research ID  A-5420-2009; ORCID 0000-0001-7369-1322).

Gegenereerd op 2016-02-09 12:41:23

Research ID: A-5420-2009


ORCID ID: 0000-0001-7369-1322


Google Scholar Citations



Publications List

 

2016


  • M.F. Lensink, S. Velankar, A. Kryshtafovych, S. Huang, D. Schneidman-Duhovny, A. Sali, J. Segura, N.s Fernandez-Fuentes, S. Viswanath, R. Elber, S. Grudinin, P. Popov, E. Neveu, Hasup Lee, M. Baek, S. Park, L. Heo, G. Rie Lee, C. Seok, S. Qin, H. Zhou, D.W. Ritchie, B. Maigret, M. Devignes, A. Ghoorah, M. Torchala, R.A.G. Chaleil, P.A. Bates, E.t Ben-Zeev, M. Eisenstein, S.S. Negi, Z. Weng, T. Vreven, B.G. Pierce, T. M. Borrman, J. Yu, F. Ochsenbein, R. Guerois, A. Vangone, J.P.G.L.M. Rodrigues, G. van Zundert, M. Nellen, L. Xue, E. Karaca, A.S.J. Melquiond, K. Visscher, P.L. Kastritis, A.M.J.J. Bonvin, X. Xu, L. Qiu, C. Yan, J. Li, Z. Ma, J. Cheng, X. Zou, Y. Shen, L.X. Peterson, H. Kim, A. Roy, X. Han, J. Esquivel-Rodriguez, D. Kihara, X. Yu, N.J. Bruce, J.C. Fuller, R.C. Wade, I. Anishchenko, P.J. Kundrotas, I.A. Vakser, K. Imai, K.i Yamada, T. Oda, T. Nakamura, K. Tomii, C. Pallara, M. Romero-Durana, B. Jimenez-Garcia, I.H. Moal, J Fernandez-Recio, J. Young Joung, J. Yun Kim, K.g Joo, J. Lee, D. Kozakov, S. Vajda, S. Mottarella, D.R. Hall, D. Beglov, A. Mamonov, B. Xia, T. Bohnuud, C.A. Del Carpio, E. Ichiishi, N. Marze, D. Kuroda, S.S. Roy Burman, J.J. Gray, E. Chermak, L. Cavallo, R. Oliva, A. Tovchigrechko and S.J. Wodak. Prediction of homo- and hetero-protein complexes by ab-initio and template-based docking: a CASP-CAPRI experiment Proteins: Struc. Funct. & Bioinformatics, In press (2016)

  • P. Sliz, P. Meyer, S. Socias, J. Key, E. Ransey, E.C. Tjon, A. Buschiazzo, M. Lei, C. Botka, J. Withrow, D.B. Neau, K. Rajashankar, K.S. Anderson, R. Baxter, S. Blacklow, T. Boggon, A.M.J.J. Bonvin, D. Borek, T. Brett, A. Caflisch, C. Chang, W. Chazin, K.D. Corbett, M. Cosgrove, S. Crosson, S. Dhe-Paganon, E. Di Cera, C. Drennan, M. Eck, B. Eichman, Q. Fan, A. Ferré-D’Amaré, J.S. Fraser, J.C. Fromme, K. Garcia, R. Gaudet, P. Gong, S. Harrison, E. Heldwein, Z. Jia, R. Keenan, A. Kruse, M. Kvansakul, J. McLellan, Y. Modis, Y. Nam, Zb. Otwinowski, E.F. Pai, P.J. Barbosa Pereira, C. Petosa, C.S. Raman, T. Rapoport, A. Roll-Mecak, M. Rosen, G. Rudenko, J. Schlessinger, T. Schwartz, Y. Shamoo, H. Sondermann, Y. Tao, N. Tolia, O.V. Tsodikov, K.D. Westover, H. Wu, I. Foster, F. Maia, T. Gonen, T. Kirchhausen, K. Diederichs and M. Crosas. Data publication with the structural biology data grid supports live analysis. Nature Communications, In Press (2016).

  • S. Jung, J. Fischer, B. Spudy, K. Tim, F.D. Soennichsen, L. Xue, A.M.J.J. Bonvin, P. Goettig, V. Magdolen, U. Meyer-Hoffert, J. Grötzinger. The solution structure of the kallikrein-related peptidases inhibitor SPINK6Biochemical and Biophysical Research Communications, Advanced Online Publication (2016).

  • E. Deplazes, J. Davies, A.M.J.J. Bonvin, G.F. King and A.E. Mark. On the Combination of Ambiguous and Unambiguous Data in the Restraint-driven Docking of Flexible Peptides with HADDOCK: The Binding of the Spider Toxin PcTx1 to the Acid Sensing Ion channel (ASIC)1aJ. Chem. Inf. and Model., Advanced Online Publication (2016).

  • J.P.G.L.M. Rodrigues, A.S.J. Melquiond and  A.M.J.J. BonvinMolecular Dynamics Characterization of the Conformational Landscape of Small Peptides: A series of hands-on collaborative practical sessions for undergraduate studentsBiochemistry and Molecular Biology Education, Advanced Online Publication (2016).

  • A. Vangone, R. Oliva, L. Cavallo and A.M.J.J. Bonvin. Prediction of Biomolecular Complexes. In: From Protein Structure to Function with Bioinformatics. Ed. Daniel John Rigden, Springer, In Press.

  • R. Zhang, T. Eckert, T. Lutteke, S. Hanstein, A. Scheidig, A.M.J.J. Bonvin, N.E. Nifantiev, T. Kozar, R. Schauer, M. Abdulaziz Enani and H.C. Siebert. Structure-function relationship of antimicrobial peptides and proteins in respect to contact-molecules on pathogen surfacesCurrent Topics in Medicinal Chemistry16, 89-98 (2016).

 

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1997


  • R. Kaptein, A.M.J.J. Bonvin and R. Boelens Biomolecular structure and dynamics: recent experimental and theoretical advances. In: Proceedings of the Nato Summer School. Eds G. Vergoten and T. Theophanides Kluwer Academic Publisher, 189-209 (1997).

1996


1995


1994


1993


  • A.M.J.J. Bonvin Determination of biomolecular structures by NMR. Use of relaxation matrix calculations. PhD Thesis, Utrecht University (1993) ISBN 90-393-0408-4.

  • R.M.A. Knegtel, M. Katahira, J.G. Schilthuis, A.M.J.J. Bonvin, R. Boelens, D. Eib, CHECKCCIP.T. der Saag and R. Kaptein NMR studies of the human retinoic acid receptor-b DNA-binding domain: metal coordination and three dimensional structure. In: “Zinc-finger proteins in oncogenesis. DNA-binding and gene regulation”. M. Sluyser, G. AB, A.O. Brinkmann and R.A. Blankenstein (eds),  Annals of the New York Academy of Sciences 684, New York, 49-62 (1993).

  • A.M.J.J. Bonvin, R. Boelens and R. Kaptein Determination of biomolecular structures by NMR. Use of relaxation matrix calculations. In:”computer simulations of biomolecular systems: theoretical and experimental applications”. Vol.2. W.F. van Gunsteren, P.K. Weiner and A.J. Wilkinson (eds), ESCOM Science Publishers, 407-440 (1993).

  • A.M.J.J. Bonvin, J.A.C. Rullmann, R.M.J.N. Lamerichs, R. Boelens and R. KapteinEnsemble Iterative Relaxation Matrix Approach: a new NMR refinement protocol applied to the solution structure of crambin. PROTEINS: Structure, Function & Genetics 15, 385-400 (1993).

  • R.M.A. Knegtel, M. Katahira, J.G. Schilthuis, A.M.J.J. Bonvin, R. Boelens, D. Eib, P.T. der Saag and R. Kaptein The solution structure of the human retinoic acid receptor-b DNA-binding domain. J. Biomol. NMR 3, 1-17 (1993).

1992


  • J.A.C. Rullmann, A.M.J.J. Bonvin, R. Boelens and R. Kaptein Structure determination from NMR - Application to crambin In: Computation of biomolecular structures: achievements, problems and perspectives.” (Proceeding of a workshop held at Schloss Ringberg, March 1990), T.M. Jovin and D.M. Soumpasis (eds.), Springer, 1-14 (1992).

1991


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Gegenereerd op 2016-02-09 12:41:23

Research within the computational structural biology group focuses on the development of reliable bioinformatics and computational approaches to predict, model and dissect biomolecular interactions at atomic level. For this, bioinformatics data, structural information and available biochemical or biophysical experimental data are combined to drive the modelling process. This is implemented and further developed in the widely used HADDOCK software for the modelling of biomolecular complexes (http://haddock.science.uu.nl).

By following a holistic approach integrating various experimental information sources with computational structural biology methods we aim at obtaining a comprehensive description of the structural and dynamic landscape of complex biomolecular machines, adding the structural dimension to interaction networks and opening the route to systematic and genome-wide studies of biomolecular interactions.

Selected publications (from over 150)

  1. C. Dominguez, R. Boelens and A.M.J.J. Bonvin (2003). HADDOCK: A protein-protein docking approach based on biochemical or biophysical information. J. Am. Chem. Soc. 125, 1731-1737.
  2. A.M.J.J. Bonvin (2006). Flexible protein-protein docking. Curr. Opin. Struct. Biol., 16, 194-200.
  3. I. Gelis, A.M.J.J. Bonvin, D. Keramisanou, A. Economou and C.G. Kalodimos. Signal sequence recognition by the translocase motor SecA studied by NMR (2007). Cell, 131, 756-769.
  4. S.J. de Vries, M. van Dijk and A.M.J.J. Bonvin (2010). The HADDOCK web server for data-driven biomolecular docking. Nature Protocols, 5, 883-897.
  5. T. Schneider, Th. Kruse, R. Wimmer, I. Wiedemann, V. Sass, U. Pag, A. Jansen, A.K. Nielsen, P.H. Mygind, D.S. Raventós, S. Neve, B. Ravn, A.M.J.J. Bonvin, L. De Maria, L. Kamenova, H.-G. Sahl and H.-H. Kristensen (2010). Plectasin, a fungal defensin antibiotic peptide, targets the bacterial cell wall precursor Lipid II. Science, 328, 1168-1172.
Project:
iNEXT
01-09-2015 tot 30-08-2019
Algemene projectbeschrijving 

The project iNEXT aims to give researchers integrated access to structural biology technologies such as NMR, electron microscopy and X-ray technologies to determine new structures and functions of proteins and their complexes. The project is funded by the European Union with 10 million Euro from its Horizon 2020 Research and Innovation programme to enabling European researchers to use unique, state-of-the-art infrastructures for structural biology from 23 research institutes in Europe.  iNEXT is coordinated from the Netherlands by prof. Rolf Boelens (Utrecht University) with dr. Anastassis Perrakis (Netherlands Cancer Institute) as deputy coordinator.

Rol: Uitvoerder Financiering
3e geldstroom - EU
Projectleden
Overige projectleden:
  • European Molecular Biology Laboratory
  • Diamond Light Source
  • Consorzio Interuniversitario Risonanze Magnetiche di Metallo Proteine
  • Goethe University Frankfurt
  • The Netherlands Cancer Institute
  • Masaryk University / CEITEC
  • Spanish National Research Council
  • Leibniz-Institut für Molekulare Pharmakologie
  • Synchrotron SOLEIL
  • Lund University / MAXIV
  • Leiden University / NeCEN
  • Leiden University Medical Center
  • European Synchrotron Radiation Facility
  • Centre National de la Recherche Scientifique / RALF-NMR
  • ESFRI Instruct
  • Aarhus University
  • European Spallation Source
  • Eötvös Loránd University
  • Instituto de Tecnologia Química e Biológica
  • University of Oulu
  • University of Patras
  • Weizmann Institute of Science
Project:
uNMR-NL
01-06-2013 tot 30-06-2021
Algemene projectbeschrijving 

The project uNMR-NL was awarded 18,5 million euro from NWO to be established as a large-scale research facility for ultra-high field NMR spectroscopy (1.2 GHz). In the new uNMR-NL facility, researchers will use magnetic nuclear resonance (NMR) and MR Imaging (MRI) to study the origin of diseases like Alzheimer’s and Parkinson’s, to identify new potential drugs, to develop new materials for batteries and solar cells and to enhance the production of crops and food quality. The project is coordinated by prof. Marc Baldus of Utrecht University and also involves the Radboud University NIjmegen, Leiden University, Wageningen University,  Eindhoven University of Technology and the public-private partnership for the analytical sciences, COAST.

Rol: Uitvoerder Financiering
2e geldstroom - NWO
Projectleden
Overige projectleden:
  • prof. dr. Arno Kentgens (RU)
  • prof. dr. Marcellus Ubbink (LU)
  • prof. dr. Huub de Groot (LU)
  • prof. dr. John van Duynhoven (WUR)
  • prof. dr. Aldrik Velders (WUR)
  • dr. Henk van As (WUR)
  • Klaas Nicolay (TU/e)
  • Oscar van den Brink (COAST)

Gegenereerd op 2016-02-09 12:41:23
Nevenfuncties
  • Former Director of Education for the Chemistry Department (Feb. 2009- Feb. 2012)
  • Editorial board member of the Biophysical Journal  (Jun. 2008 - Jun. 2014)
  • Editorial board member of Proteins: Structure, Function & Bioinformatics (since 2006)
  • Editorial Board and Editorial manager for Protein Engineering, Design, and Selection (since 2014)
  • External advisory board member of EGI-Inspire (www.egi.eu) (2010-2015)
  • Member of the wwPDB task force on integrative models (2014-2015)
Gegenereerd op 2016-02-09 12:41:23
Volledige naam
prof. dr. A.M.J.J. Bonvin Contactgegevens

Nicolaas Bloembergengebouw

Padualaan 8

3584 CH Utrecht

 

Kamer 1.22

Phone: +31 30 2533859

Phone (secr.): +31 30 2532652

Accessible via Kruytgebouw -> first floor -> bridge to Sjoerd Groenmangebouw

Gegenereerd op 2016-02-09 12:41:23
Laatst bijgewerkt op 05-02-2016