New model means parasites can run, but they can’t hide
In order to cause a successful disease outbreak, viruses, bacteria and other parasites must be able to spread both inside and outside the host. Inside the host, this entails multiplying and evading the immune system, while success outside the host revolves around survival and spreading to new hosts. All infectious diseases utilise these same processes, but some pathogens can combine them in such a way that it becomes much more difficult to predict how the parasite population will react to factors such as control measures. In her doctoral dissertation, Maite Severins described mathematical and computer models that may help scientists to better understand these difficult diseases.
Severins’ models were applied to a series of research projects in which both the disease and the model were gradually made more complex. In these projects, Severins examined diseases such as paratuberculosis in cattle, coccidosis in poultry and malaria in humans.
The models from Severins’ dissertation help explain experimental results and may be used to predict the results of control measures. They may also lead to new insights and ideas for the development of new methods for fighting infectious diseases.
|Date and time:
||University Hall, Domplein 29, Utrecht
||Faculty of Veterinary Medicine
||Infection dynamics at within-host and between-host scales
||Prof. J.A.P. Heesterbeek, PhD
||Dr. D. Klinkenberg