Welcome to the laboratory of Crystal and Structural Chemistry
Our group is focussed on crystallography with main research lines in structural biology, chemical crystallography and crystallographic methods.
For an introduction to our research plans and list of selected key publications see Research.
The group is part of the Bijvoet Center for Biomolecular Research of the Department of Chemistry, Faculty of Science of the Utrecht University.
Recent key publications:
Structures of C3b in complex with factors B and D give insight into complement convertase formation, F. Forneris, D. Ricklin, J. Wu, A. Tzekou, R.S. Wallace, J. Lambris and P. Gros, Science 330, 1816-1920 (2010).
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor, S.H.M. Rooijakkers*, J. Wu*, M. Ruyken, R. van Domselaar, K.L. Planken, A. Tzekou, D. Ricklin, J.D. Lambris, B.J.C. Janssen, J.A.G. van Strijp and P. Gros, Nature Immunology 10, 721-727 (2009).
* These authors contributed equally.
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators, J. Wu, Y.-Q. Wu, D. Ricklin, B.J.C. Janssen, J.D. Lambris and P. Gros, Nature Immunology 10
, 728-733 (2009).
Structure validation in chemical crystallography, A.L. Spek, Acta Crystallographica D65, 148-155 (2009).
Complement driven by conformational changes, P. Gros, F.J. Milder and B.J.C. Janssen, Nature Reviews Immunology 8, 48-58 (2008).
Structure of C8a-MACPF reveals mechanism of membrane attack in complement immune defense, M.A. Hadders, D.X. Beringer and P. Gros, Science 317, 1552-1554 (2007).
Determination of absolute structure using Bayesian statistics on Bijvoet differences, R.W,W. Hooft, L.H. Straver, A.L. Spek, J. Applied Crystallography 41, 96-103 (2007)