Molecular Genetics Publications
Bishopp A, Help H, El-Showk S, Weijers D, Scheres B, Friml J, Benková E, Mähönen AP, Helariutta Y. (2011) A Mutually Inhibitory Interaction between Auxin and Cytokinin Specifies Vascular Pattern in Roots. Curr Biol 21:917-926 [abstract]
Bishopp A, Lehesranta S, Vatén A, Help H, El-Showk S, Scheres B, Helariutta K, Mähönen AP, Sakakibara H, Helariutta Y. (2011) Phloem-transported cytokinin regulates polar auxin transport and maintains vascular pattern in the root meristem. Curr Biol 21:927-932 [abstract]
Li H, Lin D, Dhonukshe P, Nagawa S, Chen D, Friml J, Scheres B, Guo H, Yang Z. (2011) Phosphorylation switch modulates the interdigitated pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis. Cell Res. 21:970-978 [abstract]
Mokry M, Nijman IJ, van Dijken A, Benjamins R, Heidstra R, Scheres B, Cuppen E. (2011) Identification of factors required for meristem function in Arabidopsis using a novel next generation sequencing fast forward genetics approach. BMC Genomics 12:256 [abstract]
Ten Hove CA, Bochdanovits Z, Jansweijer VM, Koning FG, Berke L, Sanchez-Perez GF, Scheres B, Heidstra R. (2011) Probing the roles of LRR RLK genes in Arabidopsis thaliana roots using a custom T-DNA insertion set. PMB 76:69-83 [abstract]
Wachsman G, Heidstra R. (2010) The CRE/lox system as a tool for developmental studies at the cell and tissue level. Methods Mol Biol. 655:47-64 [abstract]
Baskin TI, Peret B, Baluška F, Benfey PN, Bennett M, Forde BG, Gilroy S, Helariutta Y, Hepler PK, Leyser O, Masson PH, Muday GK, Murphy AS, Poethig S, Rahman A, Roberts K, Scheres B, Sharp RE, Somerville C. (2010)
Shootward and rootward: peak terminology for plant polarity. Trends Plant Sci. 11:593-594 [abstract]
Dhonukshe P, Huang F, Galvan-Ampudia CS, Mähönen AP, Kleine-Vehn J, Xu J, Quint A, Prasad K, Friml J, Scheres B, Offringa R. (2010) Plasma membrane-bound AGC3 kinases phosphorylate PIN auxin carriers at TPRXS(N/S) motifs to direct apical PIN recycling. Development 19:3245-3255 [abstract]
Robert S, Kleine-Vehn J, Barbez E, Sauer M, Paciorek T, Baster P, Vanneste S, Zhang J, Simon S, Čovanová M, Hayashi K, Dhonukshe P, Yang Z, Bednarek SY, Jones AM, Luschnig C, Aniento F, Zažímalová E, Friml J. (2010) ABP1 mediates auxin inhibition of clathrin-dependent endocytosis in Arabidopsis. Cell 143: 111-121 [abstract]
Bennett T, Scheres B. (2010) Root development-two meristems for the price of one? Curr Top Dev Biol. 91:67-102 [abstract]
Scheres, B. (2010). Developmental Biology: roots respond to an inner calling. Nature 465, 299-300 [link]
Hassan H., Scheres B. and Blilou I. (2010) JACKDAW controls epidermal patterning in the Arabidopsis root meristem through a non-cell-autonomous mechanism. Development 137:1523-1529 [abstract]
Bennett T, van den Toorn A, Sanchez-Perez G.F, Campilho A, Willemsen V, Snel B, and Scheres B. (2010) SOMBRERO, BEARSKIN1, and BEARSKIN2 Regulate Root Cap Maturation in Arabidopsis. Plant Cell 3:640-654 [abstract]
Ten Hove CA, Willemsen V, de Vries WJ, van Dijken A, Scheres B, Heidstra R. (2010) SCHIZORIZA Encodes a Nuclear Factor Regulating Asymmetry of Stem Cell Divisions in the Arabidopsis Root. Curr Biol. 20:452-457 [abstract]
De Smet I, Lau S, Voß U, Vanneste S, Benjamins R, Rademacher EH, Schlereth A, De Rybel B, Vassileva V, Grunewald W, Naudts M, Levesque MP, Ehrismann JS, Inzé D, Luschnig C, Benfey PN, Weijers D, Van Montagu MC, Bennett MJ, Jürgens G, Beeckman T. (2010) Bimodular auxin response controls organogenesis in Arabidopsis. PNAS 107:2705-2710 [abstract]
Terpstra I, Heidstra R. (2009) Stem cells: The root of all cells. Semin Cell Dev Biol. 20:1089-1096 [abstract]
Grieneisen VA, Scheres B. (2009) Back to the future: evolution of computational models in plant morphogenesis. Curr Opin Plant Biol. 12:606-614 [abstract]
Grigg SP, Galinha C, Kornet N, Canales C, Scheres B, Tsiantis M. (2009) Repression of Apical Homeobox Genes Is Required for Embryonic Root Development in Arabidopsis. Curr Biol. 19:1485-1490 [abstract]
Tromas A, Braun N, Muller P, Khodus T, Paponov IA, Palme K, Ljung K, Lee JY, Benfey P, Murray JA, Scheres B, Perrot-Rechenmann C. (2009) The AUXIN BINDING PROTEIN 1 is required for differential auxin responses mediating root growth. PLoS One 4:e6648 [abstract]
Menke FL, Scheres B. (2009) Plant asymmetric cell division, vive la différence! Cell 137:1189-92 [abstract]
Kornet N, Scheres B. (2009) Members of the GCN5 histone acetyltransferase complex regulate PLETHORA-mediated root stem cell niche maintenance and transit amplifying cell proliferation in Arabidopsis. Plant Cell 21:1070-1079 [abstract]
Sena G, Wang X, Liu HY, Hofhuis H, Birnbaum KD. (2009) Organ regeneration does not require a functional stem cell niche in plants. Nature 457:1150-1153 [abstract]
Kornet N, Scheres B. (2009) Stem Cell Factors in Plants: Chromatin Connections. Cold Spring Harb Symp Quant Biol. 73: 235-242 [abstract]
Thomann A, Lechner E, Hansen M, Dumbliauskas E, Parmentier Y, Kieber J, Scheres B, Genschik P. (2009) Arabidopsis CULLIN3 genes regulate primary root growth and patterning by ethylene-dependent and -independent mechanisms. PLoS Genet. 5: e1000328 [abstract]
Laskowski M, Grieneisen VA, Hofhuis H, Hove CA, Hogeweg P, Marée AF, Scheres B. (2008) Root System Architecture from Coupling Cell Shape to Auxin Transport. PLoS Biol. 6: e307 [abstract]
Willemsen V, Bauch M, Bennett T, Campilho A, Wolkenfelt H, Xu J, Haseloff J, Scheres B. (2008) The NAC domain transcription factors FEZ and SOMBRERO control the orientation of cell division plane in Arabidopsis root stem cells. Dev Cell. 15: 913-922. [abstract]
Dhonukshe P, Tanaka H, Goh T, Ebine K, Mähönen AP, Prasad K, Blilou I, Geldner N, Xu J, Uemura T, Chory J, Ueda T, Nakano A, Scheres B, Friml J. (2008) Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions. Nature 456: 962-966 [abstract]
Song SK, Hofhuis H, Lee MM, Clark SE. (2008) Key divisions in the early Arabidopsis embryo require POL and PLL1 phosphatases to establish the root stem cell organizer and vascular axis. Dev Cell. 15: 98-109. [abstract]
Benjamins R, Scheres B. (2008) Auxin: the looping star in plant development. Annu Rev Plant Biol. 59: 443-465. Review [abstract]
ten Hove CA, Heidstra R. (2008) Who begets whom? Plant cell fate determination by asymmetric cell division. Curr Opin Plant Biol. 11: 34-41. Review [abstract]
Galinha C, Hofhuis H, Luijten M, Willemsen V, Blilou I, Heidstra R, Scheres B. (2007) PLETHORA proteins as dose-dependent master regulators of Arabidopsis root development. Nature 449: 1053-1057. [abstract]
Grieneisen VA, Xu J, Maree AF, Hogeweg P, Scheres B. (2007) Auxin transport is sufficient to generate a maximum and gradient guiding root growth. Nature 449: 1008-1013. [abstract]
Pérez-Pérez JM, Serralbo O, Vanstraelen M, González C, Criqui MC, Genschik P, Kondorosi E, Scheres B. (2007) Specialization of CDC27 function in the Arabidopsis thaliana anaphase-promoting complex (APC/C). Plant J. 53: 78-89. [abstract]
Welch D, Hassan H, Blilou I, Immink R, Heidstra R, Scheres B. (2007) Arabidopsis JACKDAW and MAGPIE zinc finger proteins delimit asymmetric cell division and stabilize tissue boundaries by restricting SHORT-ROOT action. Genes Dev. 21: 2196-2204. [abstract]
Scheres B. (2007) Stem-cell niches: nursery rhymes across kingdoms. Nat Rev Mol Cell Biol. 8: 345-354. [abstract]
Cui H, Levesque M, Vernoux T, Jung J, Paquette A, Gallagher K, Wang J, Blilou I, Scheres B, and Benfey P. (2007) An Evolutionarily Conserved Mechanism Delimiting SHR Movement Defines a Single Layer of Endodermis in Plants. Science 316: 421-425. [abstract]
Heidstra R. (2007) Asymmetric Cell Division in Plant Development. Progress in Molecular and Subcellular Biology. 45: 1-37. Review [abstract]
Sarkar AK, Luijten M, Miyashima S, Lenhard M, Hashimoto T, Nakajima K, Scheres B, Heidstra R, Laux T. (2007) Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers. Nature 446: 811-814. [abstract]
Alpi A, Amrhein N, Bertl A, Blatt MR, Blumwald E, Cervone F, Dainty J, De Michelis MI, Epstein E, Galston AW, Goldsmith MH, Hawes C, Hell R, Hetherington A, Hofte H, Juergens G, Leaver CJ, Moroni A, Murphy A, Oparka K, Perata P, Quader H, Rausch T, Ritzenthaler C, Rivetta A, Robinson DG, Sanders D, Scheres B, Schumacher K, Sentenac H, Slayman CL, Soave C, Somerville C, Taiz L, Thiel G, Wagner R. (2007) Plant neurobiology: no brain, no gain? Trends Plant Sci. 12:135-136.
Ioio RD, Linhares FS, Scacchi E, Casamitjana-Martinez E, Heidstra R, Costantino P, Sabatini S. (2007) Cytokinins Determine Arabidopsis Root-Meristem Size by Controlling Cell Differentiation. Curr Biol. 17: 678-82. [abstract]
Benschop JJ, Mohammed S, O'flaherty M, Heck AJ, Slijper M, Menke FL. (2007) Quantitative phospho-proteomics of early elicitor signalling in Arabidopsis. Mol Cell Proteomics 6:1198-1214. [abstract]
Hejatko J, Blilou I, Brewer PB, Friml J, Scheres B, Benkova E. (2006) In situ hybridization technique for mRNA detection in whole mount Arabidopsis samples. Nat Protoc. 1: 1939-1946. [abstract]
Campilho A, Garcia B, Toorn HV, Wijk HV, Campilho A, Scheres B. (2006) Time-lapse analysis of stem-cell divisions in the Arabidopsis thaliana root meristem. Plant J. 48: 619-627 [abstract]
Fischer U, Ikeda Y, Ljung K, Serralbo O, Singh M, Heidstra R, Palme K, Scheres B, Grebe M. (2006) Vectorial information for Arabidopsis planar polarity is mediated by combined AUX1, EIN2, and GNOM activity. Curr Biol. 16: 2143-2149 [abstract]
Serralbo O, Perez-Perez JM, Heidstra R, Scheres B. (2006) Non-cell-autonomous rescue of anaphase-promoting complex function revealed by mosaic analysis of HOBBIT, an Arabidopsis CDC27 homolog. Proc Natl Acad Sci USA. 103: 13250-12255. [abstract]
Levesque M.P., Vernoux T., Busch W., Cui H., Wang J.Y., Blilou I., Hassan H., Nakajima K., Matsumoto N., Lohmann J.U., Scheres B., Benfey P.N. (2006) Whole-genome analysis of the SHORT-ROOT developmental pathway in Arabidopsis. PLoS Biol. 5, e143 [abstract]
Scheres B., Xu J. (2006) Polar auxin transport and patterning: grow with the flow. Genes Dev. 20: 922-926. [link]
Wisniewska J., Xu J., Seifertova D., Brewer P.B., Ruzicka K., Blilou I., Rouquie D., Benkova E., Scheres B., Friml J. (2006) Polar PIN localization directs auxin flow in plants. Science 312: 883 [abstract]
Xu J., Hofhuis H., Heidstra R., Sauer M., Friml J., Scheres B. (2006) A molecular framework for plant regeneration. Science 311: 385-388. [abstract] [full text]
Friml J., Benfey P., Benkova E., Bennett M., Berleth T., Geldner N., Grebe M., Heisler M., Hejatko J., Jurgens G., Laux T., Lindsey K., Lukowitz W., Luschnig C., Offringa R., Scheres B., Swarup R., Torres-Ruiz R., Weijers D., Zazimalova E. (2005) Apical-basal polarity: why plant cells don't standon their heads. Trends Plant Sci. 11: 12-14. [abstract]
Wildwater M., Campilho A., Perez-Perez JM., Heidstra R., Blilou I., Korthout H., Chatterjee J., Mariconti L., Gruissem W., Scheres B. (2005) The RETINOBLASTOMA-RELATED Gene Regulates Stem Cell Maintenance in Arabidopsis Roots. Cell 123: 1337-1349. [abstract]
Xu J., Scheres B. (2005) Cell polarity: ROPing the ends together. Curr. Opin. Plant Biol. 6: 613-618. [abstract]
Li Li, Jian Xu, Zhi-Hong Xu, and Hong-Wei Xue (2005) Brassinosteroids Stimulate Plant Tropisms through Modulation of Polar Auxin Transport in Brassica and Arabidopsis. Plant Cell 17: 2738-2753 [abstract]
Fiers, M. Golemiec, E., Xu, J., van der Geest, L., Heidstra, R., Stiekema, W. en Liu, C-M. (2005) The 14-amino acid CLV3, CLE19 and CLE40 peptides trigger consumption of the root meristem in Arabidopsis through a CLAVATA2-dependent pathway. Plant Cell 17: 2542-2553. [abstract]
Scheres B. (2005) Stem cells: a plant biology perspective. Cell 122: 499-504. [abstract]
Xu J., Scheres B. (2005). Dissection of Arabidopsis ADP-RIBOSYLATION FACTOR 1 function in epidermal cell polarity. Plant Cell 2: 525-536. [abstract] [full text]
Blilou I., Xu J., Wildwater M., Willemsen V., Paponov I., Friml J., Heidstra R., Aida M., Palme K. and Scheres B. (2005). The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots. Nature 433: 39-44. [abstract]
Paponov IA, Teale WD, Trebar M, Blilou I, Palme K. (2005) The PIN auxin efflux facilitators: evolutionary and functional perspectives. Trends Plant Sci. 10: 170-177. Review [abstract]
Willemsen V., Scheres B. (2004) Mechanisms of pattern formation in plant embryogenesis. Annu Rev Genet. 38: 587-614. [abstract]
Aida, M., Beis, D., Heidstra, R., Willemsen, V., Blilou, I., Galinha, C., Nussaume, L., Noh, Y.S., Amasino, R., Scheres, B. (2004) The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche. Cell 1: 109-120. [abstract]
Heidstra, R., Welch, D., Scheres, B. (2004) Mosaic analyses using marked activation and deletion clones dissect Arabidopsis SCARECROW action in asymmetric cell division. Genes Dev. 16: 1964-1949. [abstract]
Scheres, B., van den Toorn, H., Heidstra, R. (2004) Root genomics: towards digital in situ hybridization. Genome Biol. 6: 227. [abstract]
Casamitjana-Martinez, E., Hofhuis, H.F., Xu, J, Liu, C.M., Heidstra, R., Scheres, B. (2003). Root-specific CLE19 overexpression and the sol1/2 suppressors implicate a CLV-like pathway in the control of Arabidopsis root meristem maintenance. Curr. Biol. 16: 1435-41. [abstract]
Grebe, M., Xu, J., Mobius, W., Ueda, T., Nakano, A., Geuze, H.J., Rook, M.B., Scheres, B. (2003) Arabidopsis sterol endocytosis involves actin-mediated trafficking via ARA6-positive early endosomes. Curr. Biol. 16: 1378-1387. [abstract]
Willemsen, V., Friml, J., Grebe, M., Van den Toorn, A., Palme, K., Scheres, B. (2003). Cell polarity and PIN protein positioning in Arabidopsis require STEROL METHYLTRANSFERASE1 function. The Plant Cell 15: 612-625. [abstract]
Sabatini, S., Heidstra, R., Wildwater, M. and Scheres, B. (2003). SCARECROW is involved in positioning the stem cell niche in the Arabidopsis root meristem. Genes Dev. 17: 354-358. [abstract]
Capron, A., Serralbo, O., Fulop, K., Frugier, F., Parmentier, Y., Dong, A., Lecureuil, A., Guerche, P., Kondorosi, E., Scheres, B., Genschik, P. (2003) The Arabidopsis anaphase-promoting complex or cyclosome: molecular and genetic characterization of the APC2 subunit. Plant Cell 10: 2370-2382. [abstract]
Scheres B. (2002). Plant patterning: TRY to inhibit your neighbours. Curr. Biol. 12: R804-R806. [abstract]
Blilou, I., Frugier, F., Folmer, S., Serralbo O., Willemsen V., Wolkenfelt H., Eloy N.B., Ferreira P.C.G., Weisbeek P. and Scheres, B. (2002). The Arabidopsis HOBBIT gene encodes a CDC27 homologue that links the plant cell cycle to progression of cell differentiation. Genes Dev. 16: 2566-2575. [abstract]
Friml, J., Benkova E., Blilou I., Wisniewska J., Hamann T., Ljung K., Woody S., Sandberg G., Scheres B., Jürgens G., Palme K. (2002). AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Cell 108: 661-673. [abstract]
Grebe M., Friml J., Swarup R., Ljung K., Sandberg G., Terlou M., Palme K., Bennett M. and Scheres B. (2002). Cell polarity signalling in Arabidopsis involves a BFA-sensitive auxin influx pathway. Curr. Biol. 12: 329-334. [abstract]
Koornneef, M. and Scheres, B. (2001). Arabidopsis as an experimental organism. in: Encyclopedia of Life Sciences (Macmillan Publishers Ltd.).
Grebe M., Xu J. and Scheres, B. (2001). Cell axiality and polarity in plants - adding pieces to the puzzle. Curr. Op. Plant Biol. 4: 520-526. [abstract]
Scheres, B., Browse, J. (2001) Playing with Arabidopsis. Plant Physiology 2: 468-470. [link]
Scheres B. (2001). Plant cell identity: role of position and lineage. Plant Physiology 125: 112-114. [abstract]
Benfey, P.N. and Scheres, B. (2000). Root Development. Current Biology 10: 813-815. [abstract]
Scheres B. (2000). Non-linear signaling for pattern formation? Curr. Op. Plant Biol. 3: 412-417. [abstract]
Barton, K. and Scheres, B. (2000). Plants from genes: towards the information network. Curr. Op. Plant Biol. 3: 13-16. [abstract]
Sabatini, S., Beis, D., Wolkenfelt, H., Murfett, J., Guilfoyle, T., Malamy, J., Benfey, P., Leyser, O., Bechtold, N., Weisbeek P. and Scheres, B. (1999). An auxin-dependent distal organizer of pattern and polartity in the Arabidopsis root. Cell 99: 463-472. [abstract]
Scheres, B. and Benfey, P.N. (1999). Asymmetric cell division in plants. Ann. Rev. Plant Phys. Plant Molec. Biol. 50:505-537. [abstract]
Scheres, B. and Heidstra, R. (1999). Digging out roots: Pattern formation, cell division and morphogenesis in plants. Curr. Top. Dev. Biol. 45, 207-247. [abstract]
Scheres, B. (1999) Plant development and signalling. Introduction. Semin Cell Dev Biol. 2, 117-119. [link]
Dolan, L., and Scheres, B. (1998). Root pattern: shooting in the dark? Seminars in Cell & Developmental Biology 9, 201-206. [abstract]
Scheres, B. and Berleth, T. (1998). Root development: new meanings for root canals? Curr. Op. Plant Biol. 1, 32-36. [abstract]
Van den Berg, C., Hage, W., Weisbeek, P. and Scheres, B. (1998). Laser ablation in Arabidopsis roots: a tool to study cell-to-cell communication. Nato ASI Series 104, 237-250.
Scheres, B. and Wolkenfelt, H. (1998). The Arabidopsis root as a model to study plant development. Plant Phys. Bioch. 36, 21-32.
Van den Berg, C., Weisbeek, P., and Scheres, B. (1998). Cell fate in the Arabidopsis root. Planta 205, 483-491. [abstract]
Willemsen, V., Wolkenfelt, H., de Vrieze, G., Weisbeek, P. and Scheres, B. (1998). The HOBBIT gene is required for formation of the primary root meristem in the Arabidopsis embryo. Development 125, 521-531. [abstract]
Scheres, B., Sijmons, P., Van den Berg, C., McKhann, H., de Vrieze, G., Willemsen, V. and Wolkenfelt, H. (1997). Root anatomy and development, the basis for nematode parasitism. In: Cellular and molecular basis for plant-nematode interactions, F. Grundler, S. Ohl and C. Fenoll (eds.), 25-37.
Van den Berg, C., Hage, W., Willemsen, V., van der Werff, N., Wolkenfelt, H., McKhann, H., Weisbeek, P. and Scheres, B. (1997). The acquisition of cell fate in the Arabidopsis thaliana root meristem. In: Biology of root formation and development, A. Altman and Y. Waisel (eds.). Plenum Press, 21-29.
Van den Berg, C., Willemsen, V., Hendriks, C., Weisbeek, P. and Scheres, B. (1997). Short-range control of cell differentiation in the Arabidopsis root meristem. Nature 390, 287-289. [abstract]
Scheres, B. (1997). Cell signalling in root development. Curr. Op. Genet. Dev. 7, 501-506. Review. [abstract]
Scheres, B. (1996). Embryonic genes and reinforcement cues determine cell fate in the Arabidopsis thaliana root. Seminars in Cell & Developmental Biology 7, 857-865.
Scheres, B., McKhann, H. and van den Berg, C. (1996). Roots redefined: anatomical and genetic analysis of root development. Plant Physiology 111, 959-964. [abstract]
Scheres, B., McKhann, H., van den Berg, C., Willemsen, V., Wolkenfelt, H., de Vrieze, G. and Weisbeek P. (1996). Experimental and genetic analysis of root development in Arabidopsis thaliana. Plant and Soil 187, 97-105.
Van den Berg, C., Willemsen, V., Hage, W., Weisbeek, P., and Scheres, B., (1995). Cell fate in the Arabidopsis root determined by directional signalling. Nature 378, 62-65. [abstract]
Scheres,B., DiLaurenzio,L, Willemsen,V., Hauser,M.-T., Janmaat, K., Weisbeek,P. and Benfey,P (1995). Mutations affecting the radial organisation of the Arabidopsis root display specific defects throughout the embryonic axis. Development 121, 53-62. [abstract]
Scheres, B., Wolkenfelt, H., Willemsen, V., Terlouw, M., Lawson, E., Dean, C., and Weisbeek, P. (1994) Embryonic origin of the Arabidopsis primary root and root meristem initials. Development 120, 2475-2487. [abstract]
Scheres, B., Willemsen, V., Janmaat, K., Wolkenfelt, H., Dolan, L. and Weisbeek, P. (1994). Analysis of root development in Arabidopsis thaliana. Nato ASI Series 81, pp. 41-50.
Dolan, L., Janmaat, K., Willemsen, V., Linstead, P., Poethig, S., Roberts, R., and Scheres, B. (1993). Cellular organisation of the Arabidopsis thaliana root. Development 119, 71-84. [abstract]