Dissertation
Development of embryonic cells
Mammalian embryonic stem cells have the ability to develop into any type of cell – a characteristic called ‘pluripotency’. Embryonic stem cells are generated from a group of cells that have been isolated from very young embryos. Under controlled circumstances, these cells can then continue to multiply in Petri dishes (‘in vitro’) indefinitely. Leonie du Puy has studied the various circumstances pertinent to cultivation and the early development stages of porcine embryos.
Embryonic stem cells have the potential for applications in replacing diseased or damaged tissue in humans. Due to their similarity to humans in the areas of physiology, organ size and life expectancy, pigs are often used as an animal model for biomedical research. Porcine embryonic stem cells may therefore be used to test cell therapies, as well as serving as a source for the production of in vitro meat.
Several attempts at generating embryonic stem cells from pigs have been documented. The next step, the cultivation of porcine embryonic stem cell lines that can continue multiplying indefinitely while maintaining their pluripotency, has not yet been successful. Leonie du Puy’s research is a significant step towards the eventual development of porcine embryonic stem cell lines.
| Date and time: |
1/7/2010 9:30 AM |
| Location: |
University Hall, Domplein 29, Utrecht.
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| PhD student: |
Leonie du Puy |
| Faculty: |
Faculty of Veterinary Medicine |
| Thesis: |
Pathways in pluripotency and differentiation of embryonic cells |
| Supervisor 1: |
Prof. H.P. Haagsman, PhD |
| Supervisor 2: |
Prof. B. Colenbrander, PhD, DVM |
| Co-supervisor 1: |
Dr B.A.J. Roelen |